Exploring Protection from Methotrexate-Induced Teratogenicity in Flies
نویسندگان
چکیده
منابع مشابه
Exploring protection from methotrexate-induced teratogenicity in flies.
For virtually all drug therapies, there exists a balance between efficacy and toxicity. This is particularly true in the treatment of many forms of cancer; such treatment often entails relatively nonspecific targeting of rapidly dividing cells by a variety of toxic agents. Clearly, the therapeutic efficacy of existing treatments would be improved if the toxicity of these agents could be reduced...
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The folic acid analog methotrexate (MTX), a competitive inhibitor of dihydrofolate reductase (DHFR), is used to treat a variety of cancers and autoimmune disorders. However, MTX also causes a wide range of toxic effects in healthy cells and is an established teratogen. Efforts to "rescue" the defects caused by MTX by administering a folate analog or by transgenic expression of a DHFR with an al...
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Methotrexate (Mtx), an antifolate, is used as an anti-cancer drug in higher doses such as lymphoma, breast carcinoma, sarcoma, breast cancer (Choudhury et al., 2000; Miyazaki et al., 2003; Seigers et al., 2008; Findlay et al., 2008; D’Adamo, 2011) and also in lower doses in the treatment of rheumatic diseases, psoriasis, refractory inflammatory bowel disease since it has immunosuppressant effec...
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The Sprague-Dawley rat was used to demonstrate the effect of nitrous oxide, with and without folinic pretreatment, on reproductive indices and fetal development. One of the objectives of the investigation was to test the hypothesis that at least some of the teratogenic effect of nitrous oxide is related to interference with folate metabolism. Groups of animals were exposed to 70-75% nitrous oxi...
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Caffeine consumption is worldwide. It has been part of our diet for many centuries; indwelled in our foods, drinks, and medicines. It is often perceived as a "legal drug", and though it is known to have detrimental effects on our health, more specifically, disrupt the normal fetal development following excessive maternal intake, much ambiguity still surrounds the precise mechanisms and conseque...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2007
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfm198